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mysql buffer pool how monitor (no replies)

The memory size of my server is 128GB with a 4-core processor, and I have configured the MySQL buffer pool to 12GB. Every time when concurrent requests start, I notice that the MySQL service becomes slow, with FREE_BUFFERS approaching 0, server I/O reaching 100%, and CPU usage spiking to 400%. Despite having reasonable indexes for queries. How should I adjust the MySQL buffer pool size to avoid the aforementioned issues, or which MySQL metrics should I monitor to set alerts for the server to prevent crashes?

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