InnoDB becomes too slow after some minutes of processing (no replies)

Dear users.

I am processing much data... it looks fast in general, but at some point, the processing becomes very slow, and inserting a single row may take many seconds. Then it becomes faster, and slower again. I think, it can be fixed by changing a innodb parameter, but I am not expert on in. I get this information status from the workbench. If you have a suggestion, please let me know.

Thanks in advance!

Innodb_buffer_pool_pages_data............. 65461
Innodb_buffer_pool_pages_dirty............ 1416
Innodb_buffer_pool_pages_flushed.......... 9551484
Innodb_buffer_pool_pages_free............. 0
Innodb_buffer_pool_pages_misc............. 75
Innodb_buffer_pool_pages_total............ 65536
Innodb_buffer_pool_read_ahead............. 18490320
Innodb_buffer_pool_read_ahead_evicted..... 260540
Innodb_buffer_pool_read_requests.......... 623387986
Innodb_buffer_pool_reads.................. 858301
Innodb_buffer_pool_wait_free.............. 0
Innodb_buffer_pool_write_requests......... 203426499
Innodb_data_fsyncs........................ 501279
Innodb_data_pending_fsyncs................ 1
Innodb_data_pending_reads................. 0
Innodb_data_pending_writes................ 0
Innodb_data_read.......................... 3643084800
Innodb_data_reads......................... 19358853
Innodb_data_writes........................ 5330046
Innodb_data_written....................... 68549120
Innodb_dblwr_pages_written................ 4775870
Innodb_dblwr_writes....................... 46160
Innodb_have_atomic_builtins............... ON
Innodb_log_waits.......................... 0
Innodb_log_write_requests................. 252976721
Innodb_log_writes......................... 392410
Innodb_os_log_fsyncs...................... 387129
Innodb_os_log_pending_fsyncs.............. 1
Innodb_os_log_pending_writes.............. 0
Innodb_os_log_written..................... 2486943232
Innodb_page_size.......................... 16384
Innodb_pages_created...................... 4474855
Innodb_pages_read......................... 19358606
Innodb_pages_written...................... 4775742
Innodb_row_lock_current_waits............. 0
Innodb_row_lock_time...................... 0
Innodb_row_lock_time_avg.................. 0
Innodb_row_lock_time_max.................. 0
Innodb_row_lock_waits..................... 0
Innodb_rows_deleted....................... 233164
Innodb_rows_inserted...................... 65202059
Innodb_rows_read.......................... 463282477
Innodb_rows_updated....................... 164994